Effects of omeprazole and cisapride treatment in Japanese asthmatics with reflux esophagitis

Effects of omeprazole and cisapride treatment in Japanese asthmatics with reflux esophagitis

Blog Article

In the United States and Europe, gastroesophageal reflux (GER) is receiving attention as a potential cause of bronchial asthma.Few Japanese case reports have described this relationship.Therefore, we investigated the effect of omeprazole and cisapride on pulmonary function tests, blood gases and home peak expiratory flow rates (PEFR) in six Japanese outpatients with Tumbler Cup asthma and proven GER.After 8 weeks of treatment, reflux esophagitis had improved in all patients.However, the parameters of pulmonary function showed no change other than a significant post- treatment increase in SKIN HAIR home PEFR (4.

4-27.7%) in three patients.These results suggest that anti-reflux (omeprazole and cisapride) treatment will produce small improvements in the PEFR in some Japanese asthmatics with GER.